benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate
CAS No.:1200572-69-5
Molecular Formula:C₂₈H₂₈N₂O₈S
Molecular Weight:552.605
Hs Code.:

Synonyms:benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

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Chemical Property of benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

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Technology Process of benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

There total 3 articles about benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 94832-06-1
1-bromo-4-(methylsulfonyl)-2-nitrobenzene

: 1200575-51-4
benzyl 4-(6-bromo-4H-1,3-benzodioxin-2-yl)piperidine-1-carboxylate

: 1200572-69-5
benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

Guidance literature:: benzyl 4-(6-bromo-4H-1,3-benzodioxin-2-yl)piperidine-1-carboxylate; With potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; at 90 ℃; for 1h;

1-bromo-4-(methylsulfonyl)-2-nitrobenzene; With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 15h;

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1200572-69-5
benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / chloroform / 3 h / Molecular sieve; Dean-Stark apparatus; Reflux

2.1: potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 1 h / 90 °C

2.2: 15 h / 90 °C

With potassium acetate; toluene-4-sulfonic acid; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; chloroform;

Reference yield:

: 2316-64-5
5-bromo-2-hydroxybenzyl alcohol

: 1200572-69-5
benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / chloroform / 3 h / Molecular sieve; Dean-Stark apparatus; Reflux

2.1: potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 1 h / 90 °C

2.2: 15 h / 90 °C

With potassium acetate; toluene-4-sulfonic acid; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; chloroform;