benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate

Base Information

Chemical Name:benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate
CAS No.:1200572-74-2
Molecular Formula:C₂HF₃O₂*C₃₂H₃₉N₃O₆S
Molecular Weight:707.768
Hs Code.:

Synonyms:benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate

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Chemical Property of benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate

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Technology Process of benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate

There total 6 articles about benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1200575-65-0
benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

: 108-00-9
N,N-dimethylethylenediamine

: 76-05-1
trifluoroacetic acid

: 1200572-74-2
benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate

Guidance literature:: benzyl 4-{6-[2-iodo-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate; N,N-dimethylethylenediamine; With potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 110 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1200572-71-9
benzyl 4-{6-[2-amino-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

: 1200572-74-2
benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0.33 h / 0 °C

1.2: 2 h / 20 °C

2.1: potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C

With hydrogenchloride; potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; toluene; acetonitrile;

Reference yield:

: 1200572-69-5
benzyl 4-{6-[4-(methylsulfonyl)-2-nitrophenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate

: 1200572-74-2
benzyl 4-{6-[2-{[2-(dimethylamino)ethyl]amino}-4-(methylsulfonyl)phenyl]-4H-1,3-benzodioxin-2-yl}piperidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: indium; ammonium chloride / methanol / 15 h / 85 °C

2.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0.33 h / 0 °C

2.2: 2 h / 20 °C

3.1: potassium tert-butylate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 110 °C

With hydrogenchloride; indium; potassium tert-butylate; ammonium chloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; water; toluene; acetonitrile;