Technology Process of Carbonic acid (1R,2S,5R)-1-[(E)-3-(tert-butyl-diphenyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexyl ester methyl ester
There total 4 articles about Carbonic acid (1R,2S,5R)-1-[(E)-3-(tert-butyl-diphenyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexyl ester methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R,2S,5R)-1-[(E)-3-(tert-Butyl-diphenyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexanol;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 1h;
carbonic acid dimethyl ester;
In
tetrahydrofuran; hexane;
at 0 - 20 ℃;
for 2h;
DOI:10.1021/ol048936q
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: biscyclopentadienylzirconium dichloride; lithium triethylborohydride / tetrahydrofuran / 2 h / 20 °C
1.2: 79 percent / I2 / tetrahydrofuran / 10 h / 20 °C
2.1: t-BuLi; CeCl3 / tetrahydrofuran; pentane / 1 h / -78 °C
2.2: 73 percent / tetrahydrofuran; pentane / 1 h / -78 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C
3.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C
With
n-butyllithium; cerium(III) chloride; zirconocene dichloride; tert.-butyl lithium; lithium triethylborohydride;
In
tetrahydrofuran; hexane; pentane;
DOI:10.1021/ol048936q
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: biscyclopentadienylzirconium dichloride; lithium triethylborohydride / tetrahydrofuran / 2 h / 20 °C
1.2: 79 percent / I2 / tetrahydrofuran / 10 h / 20 °C
2.1: t-BuLi; CeCl3 / tetrahydrofuran; pentane / 1 h / -78 °C
2.2: 73 percent / tetrahydrofuran; pentane / 1 h / -78 °C
3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C
3.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C
With
n-butyllithium; cerium(III) chloride; zirconocene dichloride; tert.-butyl lithium; lithium triethylborohydride;
In
tetrahydrofuran; hexane; pentane;
DOI:10.1021/ol048936q
