Technology Process of 1-(((2R,3R)-2-(benzyloxy)hex-5-en-3-yloxy)methyl)benzene
There total 4 articles about 1-(((2R,3R)-2-(benzyloxy)hex-5-en-3-yloxy)methyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,3R)-2-(benzyloxy)-5-hexen-3-ol;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
benzyl bromide;
With
tetra-(n-butyl)ammonium iodide;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
DOI:10.1016/j.tetlet.2014.05.116
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethylsulfone / dichloromethane / 2 h / -78 °C
1.2: 1 h / -78 °C
2.1: dichloromethane / 1 h / -78 - -40 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
3.2: 16 h / 20 °C
With
oxalyl dichloride; dimethylsulfone; sodium hydride;
In
tetrahydrofuran; dichloromethane;
1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Grignard Reaction;
DOI:10.1016/j.tetlet.2014.05.116
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ammonium cerium (IV) nitrate / acetonitrile; water / 1 h / 0 - 20 °C
2.1: oxalyl dichloride; dimethylsulfone / dichloromethane / 2 h / -78 °C
2.2: 1 h / -78 °C
3.1: dichloromethane / 1 h / -78 - -40 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
4.2: 16 h / 20 °C
With
ammonium cerium (IV) nitrate; oxalyl dichloride; dimethylsulfone; sodium hydride;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 3.1: |Grignard Reaction;
DOI:10.1016/j.tetlet.2014.05.116
