1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene

Base Information

• Chemical Name: 1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene
• CAS No.: 1105507-44-5
• Molecular Formula: C₁₈H₂₂O₃
• Molecular Weight: 286.371
• Mol file: 1105507-44-5.mol

Synonyms:1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene

Chemical Property of 1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene

There total 4 articles about 1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzyl bromide (100-39-0) + (2R)-1-(4-methoxybenzyloxy)propan-2-ol → 1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene (1105507-44-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1055/s-0028-1087296

Reference yield:

(R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane (80910-01-6,108836-41-5,144069-33-0,134733-19-0) → 1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene (1105507-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 16 h / 50 °C

With lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2014.05.116

Reference yield:

2-((4-methoxybenzyloxy)methyl)oxirane (108836-41-5) → 1-(((R)-1-(4-methoxybenzyloxy)propan-2-yloxy)methyl)benzene (1105507-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1: [(S,S)-N,N-bis-(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamino-Co(III)-acetate]; water / 36 h / 15 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 16 h / 50 °C

With lithium aluminium tetrahydride; [(S,S)-N,N-bis-(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamino-Co(III)-acetate]; water; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2014.05.116

upstream raw materials:

benzyl bromide

2-((4-methoxybenzyloxy)methyl)oxirane

4-Methoxybenzyl alcohol

(R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane

Downstream raw materials:

(R)-2-(benzyloxy)propan-1-ol

(2R,4R,5R)-4,5-bis(benzyloxy)hexane-1,2-diol

C₂₀H₂₆O₄

(E)-methyl 2-((S)-2-((2R,3R)-2,3-bis(benzyloxy)butyl)tetrahydro-6-oxopyran-4-ylidene)acetate