4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine

Base Information

Chemical Name:4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine
CAS No.:475662-25-0
Molecular Formula:C₃₅H₄₄N₂O₅SSi
Molecular Weight:632.896
Hs Code.:

4-[2-benzyloxymethyl-3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine

Synonyms:4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine

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Chemical Property of 4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine

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Technology Process of 4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine

There total 6 articles about 4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 67-68-5,8070-53-9
dimethyl sulfoxide

: 475662-24-9
2-benzyloxymethyl-1-(tert-butyl-diphenyl-silanyloxy)-3-(2,6-dimethoxy-pyrimidin-4-yl)-propan-2-ol

: 475662-25-0
4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine

Guidance literature:: With acetic anhydride; at 20 ℃; for 33h;
DOI:10.1248/cpb.50.1028

Reference yield:

: 2930-05-4
Benzyloxymethyl-oxiran

: 475662-25-0
4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 63 percent / H₂O; I₂ / acetonitrile / 3 h / Heating

2.1: 64 percent / N,N-dimethylpyridin-4-amine; Et₃N / CH₂Cl₂ / 30 h / 20 °C

3.1: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 5 h / Heating

4.1: n-BuLi / tetrahydrofuran / 0.5 h / -50 °C

4.2: 92 percent / tetrahydrofuran / 2 h

5.1: 69 percent / Ac₂O / 33 h / 20 °C

With dmap; n-butyllithium; water; iodine; acetic anhydride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1248/cpb.50.1028

Reference yield:

: 13071-59-5,17325-85-8,56552-80-8,4799-67-1
3-benzyloxypropan-1,2-diol

: 475662-25-0
4-[2-benzyloxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-2-methylsulfanylmethoxy-propyl]-2,6-dimethoxy-pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 64 percent / N,N-dimethylpyridin-4-amine; Et₃N / CH₂Cl₂ / 30 h / 20 °C

2.1: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 5 h / Heating

3.1: n-BuLi / tetrahydrofuran / 0.5 h / -50 °C

3.2: 92 percent / tetrahydrofuran / 2 h

4.1: 69 percent / Ac₂O / 33 h / 20 °C

With dmap; n-butyllithium; acetic anhydride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.50.1028