2α-carbomethoxy-3β-p-tolyltropane

Base Information

Chemical Name:2α-carbomethoxy-3β-p-tolyltropane
CAS No.:187093-02-3
Molecular Formula:C₁₇H₂₃NO₂
Molecular Weight:273.375
Hs Code.:

Synonyms:2α-carbomethoxy-3β-p-tolyltropane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2α-carbomethoxy-3β-p-tolyltropane

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Technology Process of 2α-carbomethoxy-3β-p-tolyltropane

There total 2 articles about 2α-carbomethoxy-3β-p-tolyltropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 4294-57-9
para-methylphenylmagnesium bromide

: 50373-10-9
methyl ecgonidine

: 130342-81-3
RTI-32

: 187093-02-3
2α-carbomethoxy-3β-p-tolyltropane

Guidance literature:: In diethyl ether; dichloromethane; at -40 ℃; for 3.5h;
DOI:10.1002/jhet.5570330676

Reference yield:

: 50-36-2
Cocaine

: 187093-02-3
2α-carbomethoxy-3β-p-tolyltropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2M aq. HCl / Heating

1.2: POCl₃ / Heating

1.3: MeOH / -40 °C

2.1: diethyl ether / -40 °C

2.2: TFA / diethyl ether / -78 °C

With hydrogenchloride; In diethyl ether; 1.1: Hydrolysis / 1.2: Chlorination / 1.3: Elimination / 2.1: Addition / 2.2: Hydrolysis;
DOI:10.1016/S0960-894X(99)00685-X