(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine

Base Information

• Chemical Name: (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine
• CAS No.: 628733-88-0
• Molecular Formula: C₂₄H₃₂ClN₅O₃
• Molecular Weight: 474.003
• Mol file: 628733-88-0.mol

Synonyms:(+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine

Chemical Property of (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine

There total 6 articles about (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(+/-)-2-(1-aminopropyl)-3-benzyl-6-chloro-3-H-pyrrolo[2,1-f][1,2,4]triazine-4-one (628733-87-9) + N-(tert-butoxycarbonyl)-3-aminopropanal (58885-60-2) → (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine (628733-88-0)

Guidance literature:

(+/-)-2-(1-aminopropyl)-3-benzyl-6-chloro-3-H-pyrrolo[2,1-f][1,2,4]triazine-4-one; N-(tert-butoxycarbonyl)-3-aminopropanal; With acetic acid; In tetrahydrofuran; at 20 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;

Reference yield:

1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester (791780-57-9) → (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine (628733-88-0)

Guidance literature:

Multi-step reaction with 4 steps

1: EDCI*HCl / CH₂Cl₂ / 20 °C

2: 25 percent / xylene / 7 h / 130 °C

3: piperidine / dimethylformamide

4: NaBH(OAc)3; AcOH / tetrahydrofuran / 20 °C

With piperidine; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; xylene;

DOI:10.1016/j.bmcl.2006.05.037

Reference yield:

(+/-)-N'-benzyl-N-FMOC-2-aminobutyrylthioamide (628733-85-7) → (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine (628733-88-0)

Guidance literature:

Multi-step reaction with 4 steps

1: EDCI*HCl / CH₂Cl₂ / 20 °C

2: 25 percent / xylene / 7 h / 130 °C

3: piperidine / dimethylformamide

4: NaBH(OAc)3; AcOH / tetrahydrofuran / 20 °C

With piperidine; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; xylene;

DOI:10.1016/j.bmcl.2006.05.037

upstream raw materials:

(+/-)-2-(1-aminopropyl)-3-benzyl-6-chloro-3-H-pyrrolo[2,1-f][1,2,4]triazine-4-one

N-(tert-butoxycarbonyl)-3-aminopropanal

1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester

(+/-)-N'-benzyl-N-FMOC-2-aminobutyrylthioamide