628733-87-9Relevant academic research and scientific papers
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors
Kim, Kyoung Soon,Lu, Songfeng,Cornelius, Lyndon A.,Lombardo, Louis J.,Borzilleri, Robert M.,Schroeder, Gretchen M.,Sheng, Christopher,Rovnyak, George,Crews, Donald,Schmidt, Robert J.,Williams, David K.,Bhide, Rajeev S.,Traeger, Sarah C.,McDonnell, Patricia A.,Mueller, Luciano,Sheriff, Steven,Newitt, John A.,Pudzianowski, Andrew T.,Yang, Zheng,Wild, Robert,Lee, Frances Y.,Batorsky, Roberta,Ryder, James S.,Ortega-Nanos, Marie,Shen, Henry,Gottardis, Marco,Roussell, Deborah L.
, p. 3937 - 3942 (2007/10/03)
Synthesis and SAR of substituted pyrrolotriazine-4-one analogues as Eg5 inhibitors are described. Many of these analogues displayed potent inhibitory activities in the Eg5 ATPase and A2780 cell proliferation assays. In addition, pyrrolotriazine-4-one anal
PYRROLOTRIAZINONE COMPOUNDS AND THEIR USE TO TREAT DISEASES
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Page 30, 31, (2010/02/04)
The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts thereof useful for inducing mitotic arrest thereby making them useful as anti-cancer agents and other diseases which can be treated by inducing mitotic arrest.
