791780-57-9

Upstream product

• 1194-96-3 4-chloro-1H-pyrrole-2-carboxylic acid methyl ester 
• 12190-75-9 chloroamine 

Downstream Products

• 628733-86-8 1-{[N-benzyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyrimidoyl]-amino}-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester 
• 1198475-34-1 6-chloropyrrolo[1,2-f][1,2,4]triazin-4(3H)-one 
• 906672-43-3 [1-(3-benzyl-6-chloro-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 628733-88-0 (+/-)-N-(3-N-BOC-aminopropyl)-N-[1-(3-benzyl-6-chloro-4-oxo-3,4-dihydropyrrolo [2,1-f][1,2,4]triazine-2-yl)]propylamine 
• 628733-87-9 (+/-)-2-(1-aminopropyl)-3-benzyl-6-chloro-3-H-pyrrolo[2,1-f][1,2,4]triazine-4-one 

Relevant academic research and scientific papers

Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors

A library of new 2-substituted pyrrolo[1,2-b]pyridazine derivatives were rapidly assembled and identified as PARP inhibitors. Structure-activity relationship for this class of inhibitor resulted in the discovery of most potent compounds 15a and 15b that e

PYRROLOTRIAZINONE DERIVATIVES

Compounds of the formula (I) in which X, R1 and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase and PARP-1 and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of imflamination.

HETEROCYCLIC COMPOUND AS PROTEIN KINASE INHIBITOR

Provided are novel heterocyclic compounds useful as anti-cancer drugs by suppressing protein kinase activities of growth factor receptors such as c-Met, pharmaceutical compositions containing the same, and methods for using the compound.

JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are pyrrolotriazine compounds for treatment of JAK kinase, including JAK2 kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Synthesis and SAR of substituted pyrrolotriazine-4-one analogues as Eg5 inhibitors are described. Many of these analogues displayed potent inhibitory activities in the Eg5 ATPase and A2780 cell proliferation assays. In addition, pyrrolotriazine-4-one anal