791780-57-9Relevant articles and documents
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors
Xiang, Hao-Yue,Chen, Jian-Yang,Huan, Xia-Juan,Chen, Yi,Gao, Zhao-bing,Ding, Jian,Miao, Ze-Hong,Yang, Chun-Hao
, (2020/12/02)
A library of new 2-substituted pyrrolo[1,2-b]pyridazine derivatives were rapidly assembled and identified as PARP inhibitors. Structure-activity relationship for this class of inhibitor resulted in the discovery of most potent compounds 15a and 15b that e
HETEROCYCLIC COMPOUND AS PROTEIN KINASE INHIBITOR
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Page/Page column 34-35, (2011/08/06)
Provided are novel heterocyclic compounds useful as anti-cancer drugs by suppressing protein kinase activities of growth factor receptors such as c-Met, pharmaceutical compositions containing the same, and methods for using the compound.
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors
Kim, Kyoung Soon,Lu, Songfeng,Cornelius, Lyndon A.,Lombardo, Louis J.,Borzilleri, Robert M.,Schroeder, Gretchen M.,Sheng, Christopher,Rovnyak, George,Crews, Donald,Schmidt, Robert J.,Williams, David K.,Bhide, Rajeev S.,Traeger, Sarah C.,McDonnell, Patricia A.,Mueller, Luciano,Sheriff, Steven,Newitt, John A.,Pudzianowski, Andrew T.,Yang, Zheng,Wild, Robert,Lee, Frances Y.,Batorsky, Roberta,Ryder, James S.,Ortega-Nanos, Marie,Shen, Henry,Gottardis, Marco,Roussell, Deborah L.
, p. 3937 - 3942 (2007/10/03)
Synthesis and SAR of substituted pyrrolotriazine-4-one analogues as Eg5 inhibitors are described. Many of these analogues displayed potent inhibitory activities in the Eg5 ATPase and A2780 cell proliferation assays. In addition, pyrrolotriazine-4-one anal
