Multi-step reaction with 10 steps
1.1: toluene-4-sulfonic acid / 23 h / Heating / reflux
2.1: sodium hydride / tetrahydrofuran / 20 °C
3.1: ammonium acetate / methanol / 2 h / Heating / reflux
4.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.08 h / 160 °C / Microwave
5.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C
6.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux
6.2: pH 1
7.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 °C
8.1: N-ethylmorpholine;; oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.75 h / 0 °C
9.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C
9.2: 2 h / 180 °C / Microwave
10.1: m-chloroperoxybenzoic acid / dichloromethane / 2 h / 0 °C
With
N-ethylmorpholine;; sodium hydroxide; m-chloroperoxybenzoic acid; oxalyl dichloride; ammonium acetate; water; sodium hydride; toluene-4-sulfonic acid; O-phenyl phosphorodichloridate; sodium t-butanolate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;