83863-74-5

Basic information

• Product Name: 2-CARBOXYMETHYL-1-METHYLPYRROLE-3-CARBOXYLIC ACID
• Synonyms: 2-CARBOXYMETHYL-1-METHYLPYRROLE-3-CARBOXYLIC ACID;3-carboxy-1-methyl-1H-pyrrole-2-acetic acid;Einecs 281-140-1;2-(Carboxymethyl)-1-methyl-1H-pyrrole-3-carboxylic acid;2-CarboxyMethyl-1-Methylp...;(3-Carboxy-1-methyl-1H-pyrrol-2-yl)acetic acid;1H-Pyrrole-2-acetic acid, 3-carboxy-1-Methyl-
• CAS NO: 83863-74-5
• Molecular Formula: C₈H₉NO₄
• Molecular Weight: 183.16
• EINECS: 281-140-1
• Mol File: 83863-74-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 414 °C at 760 mmHg
• Flash Point: 204.2 °C
• Appearance: /
• Density: 1.38
• Vapor Pressure: 1.36E-07mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 2-CARBOXYMETHYL-1-METHYLPYRROLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CARBOXYMETHYL-1-METHYLPYRROLE-3-CARBOXYLIC ACID(83863-74-5)
• EPA Substance Registry System: 2-CARBOXYMETHYL-1-METHYLPYRROLE-3-CARBOXYLIC ACID(83863-74-5)

Safety Data

• Hazardous Substances Data: 83863-74-5(Hazardous Substances Data)

Usage

General Description

2-Carboxymethyl-1-methylpyrrole-3-carboxylic acid is a molecule with the chemical formula C9H9NO5. It is a derivative of pyrrole and contains carboxylic acid groups. 2-Carboxymethyl-1-methylpyrrole-3-carboxylic acid is often used as a building block in organic synthesis and pharmaceutical research. It is known for its ability to chelate metal ions, making it useful in the development of metal-based drugs. It also has potential applications in the development of new materials, particularly in the field of coordination chemistry. Its unique structure and reactivity make it a versatile and important molecule in the field of chemistry and biochemistry.

InChI:InChI=1/C8H9NO4/c1-9-3-2-5(8(12)13)6(9)4-7(10)11/h2-3H,4H2,1H3,(H,10,11)(H,12,13)

Upstream product

• 107-20-0 2-chloroethanal 
• 542-05-2 acetonedicarboxylic acid 
• 74-89-5 methylamine 

Downstream Products

• 94133-60-5 C₁₀H₁₃NO₄ 
• 51856-79-2 N-methyl-2-(methoxycarbonylmethyl)pyrrole 
• 33369-52-7 methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate 
• 26171-23-3 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid 
• 49669-45-6 ethyl (1-methyl-1H-pyrrol-2-yl)acetate 
• 925917-92-6 1-methyl-7-(4-morpholinylcarbonyl)-4-{3-[(trifluoromethyl)oxy]phenyl}-1H-pyrrolo[3,2-c]pyridine hydrochloride 
• 925917-91-5 3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide hydrochloride 
• 925917-90-4 N-[(3-chlorophenyl)methyl]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochloride 
• 925917-53-9 4-[(3-chlorophenyl)oxy]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride 
• 925917-93-7 4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride 
• 925979-46-0 1-methyl-7-(4-morpholinylcarbonyl)-4-{3-[(trifluoromethyl)oxy]phenyl}-1H-pyrrolo[3,2-c]pyridine 
• 925979-45-9 3-chloro-N-[1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide 
• 925979-44-8 N-[(3-chlorophenyl)methyl]-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridin-4-amine 
• 925917-89-1 4-[(3-chlorophenyl)sulfonyl]-1-methyl-7-(1-piperidinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine 

Relevant articles and documents

Synthetic method of non-steroidal antiinflammatory drug pain killing

The invention discloses a synthesis method of non-steroidal anti-inflammatory drug tolmetin. The methodcomprises the following steps: sequentially preparing a sulfuric acid-containing acetonedicarboxylic acid crude product, 2-(2-acetoxy)-1-methyl-1H-pyrrole-3-formic acid and 2-(2-alkyl acetate)-1-methyl-1H-pyrrole-3-formic acid by taking citric acid or citric acid monohydrate as a raw material; and carrying out decarboxylation, acylation, hydrolysis and acidification to obtain tolmetin. The synthetic method provided by the invention overcomes the defect that the existing tolmetin preparation process depends on N-methylpyrrole, and is a low-cost, low-pollution and high-yield synthetic method of non-steroidal anti-inflammatory drug tolmetin.

PYRROLOPYRIDINE DERIVATIVES

The present invention relates to novel pyrrolopyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.