Technology Process of N-2',4',6'-triisopropylbenzenesulfonyl-N,4,9-trimethyl-3(E),7-nonadienamine
There total 4 articles about N-2',4',6'-triisopropylbenzenesulfonyl-N,4,9-trimethyl-3(E),7-nonadienamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-2',4',6'-triisopropylbenzenesulfonyl-2-pyrroline;
With
tert.-butyl lithium;
In
diethyl ether; pentane;
at -78 - 0 ℃;
for 0.833333h;
2-methylpent-2-en-5-yl lithium;
In
diethyl ether; pentane;
at 20 ℃;
for 3h;
methyl iodide;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
diethyl ether; pentane;
at 20 ℃;
for 1h;
Further stages.;
DOI:10.1021/jo001386z
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / tetrahydrofuran; diethyl ether / 2 h / 0 °C
1.2: 96 percent / tetrahydrofuran; diethyl ether / 6 h / 0 - 20 °C
2.1: 74 percent / DIBAL-H / CH2Cl2 / 0.17 h / 0 °C
3.1: 90 percent / citric acid monohydrate / toluene / 3 h / Heating
4.1: tBuLi / diethyl ether; pentane / 0.83 h / -78 - 0 °C
4.2: CuCN / diethyl ether; pentane / 3 h / 20 °C
4.3: 73 percent / HMPA / diethyl ether; pentane / 1 h / 20 °C
With
tert.-butyl lithium; sodium hydride; diisobutylaluminium hydride; citric acid;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene; pentane;
DOI:10.1021/jo001386z
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 74 percent / DIBAL-H / CH2Cl2 / 0.17 h / 0 °C
2.1: 90 percent / citric acid monohydrate / toluene / 3 h / Heating
3.1: tBuLi / diethyl ether; pentane / 0.83 h / -78 - 0 °C
3.2: CuCN / diethyl ether; pentane / 3 h / 20 °C
3.3: 73 percent / HMPA / diethyl ether; pentane / 1 h / 20 °C
With
tert.-butyl lithium; diisobutylaluminium hydride; citric acid;
In
diethyl ether; dichloromethane; toluene; pentane;
DOI:10.1021/jo001386z
