methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt

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Chemical Name:methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt
CAS No.:1165923-72-7
Molecular Formula:CH₂O₂*C₂₅H₂₆N₄O₄
Molecular Weight:492.532
Hs Code.:

Synonyms:methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt

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Chemical Property of methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt

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Technology Process of methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt

There total 1 articles about methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 64-18-6
formic acid

: 3395-91-3
Methyl 3-bromopropionate

: 1165923-29-4
2-isopropoxy-5-(3-(1,2,3,4-tetrahydroisoquinolin-5-yl)-1,2,4-oxadiazol-5-yl)benzonitrile

: 1165923-72-7
methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt

Guidance literature:: Methyl 3-bromopropionate; 2-isopropoxy-5-(3-(1,2,3,4-tetrahydroisoquinolin-5-yl)-1,2,4-oxadiazol-5-yl)benzonitrile; With caesium carbonate; In N,N-dimethyl-formamide; at 20 - 150 ℃; for 4.08333h; Microwave irradiation;

formic acid;

Reference yield: 100.0%

: 1165923-72-7
methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt

: 1165923-34-1
3-(5-(5-(3-cyano-4-(1-methylethyloxy)phenyl)-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoic acid hydrochloride

Guidance literature:: methyl 3-(5-(5-(3-cyano-4-((1-methylethyloxy)phenyl))-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2(1H)-isoquinolinyl)propanoate, formic acid salt; With lithium hydroxide; water; In tetrahydrofuran; methanol; at 100 ℃; for 0.05h; Microwave irradiation;

With hydrogenchloride; In tetrahydrofuran; methanol; water;