(R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate
CAS No.:1425504-22-8
Molecular Formula:C₂₆H₂₆ClN₅O₂
Molecular Weight:475.978
Hs Code.:

Synonyms:(R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate

Suppliers and Price of (R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate

There total 5 articles about (R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 578729-21-2
[(R)-1-(4-bromo-phenyl)-ethyl]-carbamic acid tert-butyl ester

: 1425504-19-3
8-chloro-6-(pyridin-4-yl)quinazolin-2-amine

: 1425504-22-8
(R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate

Guidance literature:: With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; for 12h;
DOI:10.1021/jm301658d

Reference yield:

: 24358-62-1,27298-97-1,45791-36-4,64313-06-0
(R)-1-(4-bromophenyl)ethylamine

: 1425504-22-8
(R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 12 h / 20 °C

2: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 1,4-dioxane / 12 h / 90 °C

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm301658d

Reference yield:

: 166527-08-8
2-amino-5-bromo-3-chlorobenzaldehyde

: 1425504-22-8
(R)-tert-butyl 1-(4-(8-chloro-6-(pyridin-4-yl)quinazolin-2-ylamino)phenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl acetamide / 4 h / 140 °C

1.2: 16 h

2.1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 12 h / 90 °C

3.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 1,4-dioxane / 12 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl acetamide; water;
DOI:10.1021/jm301658d