3-(1-Methyl-3,4-dihydronaphthalen-2-yl)pyridine

Base Information

Chemical Name:3-(1-Methyl-3,4-dihydronaphthalen-2-yl)pyridine
CAS No.:3614-50-4
Molecular Formula:C₁₆H₁₅N
Molecular Weight:221.302
Hs Code.:2933399090
UNII:ZPB349KCU5
DSSTox Substance ID:DTXSID90424897
Wikidata:Q82237665
Pharos Ligand ID:UB5VDC31LCMF
ChEMBL ID:CHEMBL206283
Mol file:3614-50-4.mol

Synonyms:3614-50-4;3-(1-methyl-3,4-dihydronaphthalen-2-yl)pyridine;3-(1-methyl-3,4-dihydronaphthalen-2-yl)-pyridine;Dihydronaphthalene 6;D0K5KG;ZPB349KCU5;BDBM8892;CHEMBL206283;SCHEMBL4514804;DTXSID90424897;AKOS015965701;AC-20696;PD180782;5-Ethoxycarbonylindole-2-carboxylicacidethylester;3-(1-Methyl-3,4-dihydronaphthalin-2-yl)pyridine;3-(3,4-Dihydro-1-methyl-2-naphthalenyl)pyridine;Pyridine, 3-(3,4-dihydro-1-methyl-2-naphthalenyl)-

Suppliers and Price of 3-(1-Methyl-3,4-dihydronaphthalen-2-yl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-(1-METHYL-3,4-DIHYDRO-NAPHTHALEN-2-YL)-PYRIDINE 95.00%
5MG
$ 500.04

Total 3 raw suppliers

Chemical Property of 3-(1-Methyl-3,4-dihydronaphthalen-2-yl)pyridine

Chemical Property:

Vapor Pressure:5.46E-05mmHg at 25°C
Refractive Index:1.604
Boiling Point:357.9°C at 760 mmHg
Flash Point:155.3°C
PSA：12.89000
Density:1.09g/cm³
LogP:3.95850
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:221.120449483
Heavy Atom Count:17
Complexity:305

Purity/Quality:: 3-(1-METHYL-3,4-DIHYDRO-NAPHTHALEN-2-YL)-PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(CCC2=CC=CC=C12)C3=CN=CC=C3

Technology Process of 3-(1-Methyl-3,4-dihydronaphthalen-2-yl)pyridine

There total 7 articles about 3-(1-Methyl-3,4-dihydronaphthalen-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 93008-02-7
1-methyl-2-pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-1-ol

: 3614-50-4
3-<1-Methyl-3.4-dihydro-naphthyl-(2)>-pyridin

Guidance literature:: With hydrogenchloride; at 100 ℃; for 2h;
DOI:10.1021/jm060055x

Reference yield:

: 6443-85-2
3-pyridinylacetonitrile

: 3614-50-4
3-<1-Methyl-3.4-dihydro-naphthyl-(2)>-pyridin

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaNH₂ / dimethylformamide / 2 h / 20 - 80 °C

1.2: 47 percent / dimethylformamide / 4 h / 20 - 80 °C

2.1: 74 percent / aq. NaOH / ethanol / 24 h / Heating

3.1: 90 percent / polyphosphoric acid / 0.33 h / 110 °C

4.1: 41 percent / tetrahydrofuran; toluene / 3 h / Heating

5.1: 63 percent / aq. HCl / 2 h / 100 °C

With hydrogenchloride; sodium hydroxide; PPA; sodium amide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 4.1: Grignard reaction;
DOI:10.1021/jm060055x

Reference yield:

: 653-56-5
2-pyridin-3-yl-3,4-dihydro-2H-naphthalen-1-one

: 3614-50-4
3-<1-Methyl-3.4-dihydro-naphthyl-(2)>-pyridin

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / tetrahydrofuran; toluene / 3 h / Heating

2: 63 percent / aq. HCl / 2 h / 100 °C

With hydrogenchloride; In tetrahydrofuran; toluene; 1: Grignard reaction;
DOI:10.1021/jm060055x