1-Methyl-2-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol

Base Information

Chemical Name:1-Methyl-2-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
CAS No.:93008-02-7
Molecular Formula:C₁₆H₁₇NO
Molecular Weight:239.317
Hs Code.:2933399090
DSSTox Substance ID:DTXSID70470170
Mol file:93008-02-7.mol

Synonyms:93008-02-7;1-Methyl-2-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol;1-METHYL-2-PYRIDIN-3-YL-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-OL;SCHEMBL13712390;DTXSID70470170;AKOS015965744

Suppliers and Price of 1-Methyl-2-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-METHYL-2-PYRIDIN-3-YL-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-OL 95.00%
5MG
$ 501.78

Total 7 raw suppliers

Chemical Property of 1-Methyl-2-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol

Chemical Property:

PSA：33.12000
LogP:3.01910
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:239.131014166
Heavy Atom Count:18
Complexity:293

Purity/Quality:

99% ^*data from raw suppliers

1-METHYL-2-PYRIDIN-3-YL-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-OL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(CCC2=CC=CC=C21)C3=CN=CC=C3)O

Technology Process of 1-Methyl-2-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol

There total 6 articles about 1-Methyl-2-(pyridin-3-yl)-1,2,3,4-tetrahydronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 653-56-5
2-pyridin-3-yl-3,4-dihydro-2H-naphthalen-1-one

: 676-58-4
methylmagnesium chloride

: 93008-02-7
1-methyl-2-pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:: In tetrahydrofuran; toluene; for 3h; Heating;
DOI:10.1021/jm060055x

Reference yield:

: 6443-85-2
3-pyridinylacetonitrile

: 93008-02-7
1-methyl-2-pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaNH₂ / dimethylformamide / 2 h / 20 - 80 °C

1.2: 47 percent / dimethylformamide / 4 h / 20 - 80 °C

2.1: 74 percent / aq. NaOH / ethanol / 24 h / Heating

3.1: 90 percent / polyphosphoric acid / 0.33 h / 110 °C

4.1: 41 percent / tetrahydrofuran; toluene / 3 h / Heating

With sodium hydroxide; PPA; sodium amide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 4.1: Grignard reaction;
DOI:10.1021/jm060055x

Reference yield:

: 6529-39-1
4-phenyl-2-(pyridin-3-yl)butyric acid

: 93008-02-7
1-methyl-2-pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / polyphosphoric acid / 0.33 h / 110 °C

2: 41 percent / tetrahydrofuran; toluene / 3 h / Heating

With PPA; In tetrahydrofuran; toluene; 2: Grignard reaction;
DOI:10.1021/jm060055x