2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine

Base Information

• Chemical Name: 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine
• CAS No.: 672343-15-6
• Molecular Formula: C₁₄H₂₄INOSi
• Molecular Weight: 377.341
• Mol file: 672343-15-6.mol

Synonyms:2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine

Chemical Property of 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine

There total 4 articles about 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(tert-butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amine (854691-01-3) → 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine (672343-15-6)

Guidance literature:

(tert-butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amine; With n-butyllithium; In diethyl ether; hexane; at -78 - 20 ℃; for 4h;

With iodine; In diethyl ether; hexane; at -78 - 20 ℃;

DOI:10.1021/ol0362717

Reference yield:

D-2-phenylglycinol (56613-80-0) → 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine (672343-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: n-BuLi / diethyl ether; hexane / 4 h / -78 - 20 °C

2.2: 2.27 g / I₂ / diethyl ether; hexane / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/ol0362717

Reference yield:

D-2-phenylglycinol (56613-80-0) → 2-(tert-butyl-dimethyl-silanyloxy)-(1R)-(2-iodo-phenyl)-ethylamine (672343-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

2.1: n-BuLi / diethyl ether; hexane / -78 - 20 °C

2.2: 2.27 g / I₂ / diethyl ether; hexane / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1016/j.tet.2005.03.111

upstream raw materials:

(tert-butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-ethyl]-amine

D-2-phenylglycinol

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-tert-butyl-(4R)-(2-iodo-phenyl)-4,5-dihydro-oxazole