methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate

Base Information

Chemical Name:methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate
CAS No.:1383783-24-1
Molecular Formula:C₂₉H₂₉F₃N₄O₇
Molecular Weight:602.567
Hs Code.:

Synonyms:methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate

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Chemical Property of methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate

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Technology Process of methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate

There total 8 articles about methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1679-64-7
Monomethyl terephthalate

: 1383783-23-0
(E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide

: 1383783-24-1
methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1383740-01-9
(Z)-N-hydroxy-2-(trifluoromethoxy)benzimidoyl chloride

: 1383783-24-1
methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / tetrahydrofuran / 0.5 h / -10 °C

1.2: 6 h / -5 - 35 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

4.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h

6.1: potassium carbonate / dichloromethane; water / 2 h

7.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 60 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; hydroxylamine hydrochloride; potassium tert-butylate; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1383740-03-1
5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

: 1383783-24-1
methyl 4-((((amino(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)methylene)amino)oxy)carbonyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dichloromethane; water / 2 h

2: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;