5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

Base Information

Chemical Name:5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole
CAS No.:1383740-03-1
Molecular Formula:C₁₉H₂₁F₃N₂O₃
Molecular Weight:382.383
Hs Code.:

Synonyms:5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

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Chemical Property of 5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

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Technology Process of 5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

There total 9 articles about 5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1383740-02-0
tert-butyl 4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidine-1-carboxylate

: 1383740-03-1
5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112910

Reference yield:

: 94651-33-9
2-(trifluoromethoxy)benzaldehyde

: 1383740-03-1
5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 1 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

3.1: potassium carbonate / tetrahydrofuran / 0.5 h / -10 °C

3.2: 6 h / -5 - 35 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

6.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 1 h

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; hydroxylamine hydrochloride; potassium tert-butylate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: (5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)-methanol

: 1383740-03-1
5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

2: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h

With 18-crown-6 ether; carbon tetrabromide; potassium tert-butylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;