(E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide

Base Information

Chemical Name:(E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide
CAS No.:1383783-23-0
Molecular Formula:C₂₀H₂₃F₃N₄O₄
Molecular Weight:440.422
Hs Code.:

Synonyms:(E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide

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Chemical Property of (E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide

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Technology Process of (E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide

There total 7 articles about (E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383743-96-1
4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidine-1-carbonitrile

: 1383783-23-0
(E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; at 60 ℃; for 2h;

Reference yield:

: 1383740-01-9
(Z)-N-hydroxy-2-(trifluoromethoxy)benzimidoyl chloride

: 1383783-23-0
(E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / tetrahydrofuran / 0.5 h / -10 °C

1.2: 6 h / -5 - 35 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h

4.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1 h

6.1: potassium carbonate / dichloromethane; water / 2 h

7.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 60 °C

With lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; hydroxylamine hydrochloride; potassium tert-butylate; sodium acetate; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 1383740-03-1
5-cyclopropyl-4-((piperidin-4-yloxy)methyl)-3-(2-(trifluoromethoxy)phenyl)isoxazole

: 1383783-23-0
(E)-4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-N'-hydroxypiperidine-1-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane; water / 2 h

2: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 60 °C

With hydroxylamine hydrochloride; sodium acetate; potassium carbonate; In ethanol; dichloromethane; water;