2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine

Base Information

• Chemical Name: 2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine
• CAS No.: 127040-82-8
• Molecular Formula: C₁₇H₁₈N₂S₂
• Molecular Weight: 314.475
• Mol file: 127040-82-8.mol

Synonyms:2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine

Chemical Property of 2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine

There total 3 articles about 2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(3-butenyl)-N'-phenylthiourea (33522-07-5) + benzenesulfenyl chloride (931-59-9) → 2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine (127040-82-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.5h; Ambient temperature;

DOI:10.1007/BF00807436

Reference yield: 78.0%

sodium thiophenolate (930-69-8) + (6-Iodomethyl-5,6-dihydro-4H-[1,3]thiazin-2-yl)-phenyl-amine (127040-72-6) → 2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine (127040-82-8)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)99382-1

Reference yield:

N-(3-butenyl)-N'-phenylthiourea (33522-07-5) → 2-(N-Phenylamino)-6-phenylthiomethyl-5,6-dihydro-4H-1,3-thiazine (127040-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / iodine / CH₂Cl₂

2: 78 percent / dimethylformamide

With iodine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)99382-1

upstream raw materials:

sodium thiophenolate

(6-Iodomethyl-5,6-dihydro-4H-[1,3]thiazin-2-yl)-phenyl-amine

N-(3-butenyl)-N'-phenylthiourea

benzenesulfenyl chloride