14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate

Base Information

Chemical Name:14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate
CAS No.:1350636-83-7
Molecular Formula:C₃H₆O₃*C₂₈H₄₅NO₅S
Molecular Weight:597.814
Hs Code.:

Synonyms:14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate

Chemical Property:

Purity/Quality:

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Technology Process of 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate

There total 19 articles about 14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-33-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6
L-Lactic acid

: 1061337-51-6
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin

: 1350636-83-7
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate

Guidance literature:: In ethyl acetate; at 25 - 50 ℃; for 3h;

Reference yield:

: 31716-01-5
pleuromutilin tosylate

: 1350636-83-7
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

2.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

2.2: 1.5 h / 0 - 25 °C / Industry scale

3.1: ethyl acetate / 3 h / 25 - 50 °C

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In tert-butyl methyl ether; water; ethyl acetate; isopropyl alcohol;

Reference yield:

: pleuromutilin

: 1350636-83-7
14-O-{[(1R,2R,4R)-4-amino-2-hydroxy-cyclohexylsulfanyl]-acetyl}-mutilin L-lactate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / dichloromethane / 20.33 h / 10 - 25 °C / Reflux; Industry scale

2.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

3.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

3.2: 1.5 h / 0 - 25 °C / Industry scale

4.1: ethyl acetate / 3 h / 25 - 50 °C

With phosphoric acid; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In dichloromethane; tert-butyl methyl ether; water; ethyl acetate; isopropyl alcohol;