trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester
CAS No.:1418003-21-0
Molecular Formula:C₁₉H₂₇N₅O₂
Molecular Weight:357.456
Hs Code.:

Synonyms:trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

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Chemical Property of trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

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Technology Process of trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

There total 2 articles about trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85967-19-7
4-chloro-3-nitro-[1,5]naphthyridine

: 1418003-21-0
trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

2: ammonium chloride; iron / water / 3.5 h / 80 °C

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In water; isopropyl alcohol;

Reference yield:

: 195314-59-1
tert-butyl (4-aminocyclohexyl)carbamate

: 1418003-21-0
trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.33 h / 120 °C / Microwave irradiation

2: ammonium chloride; iron / water / 3.5 h / 80 °C

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; In water; isopropyl alcohol;

Reference yield: 47.0%

: 598-81-2
(R)-lactamide

: 1418003-21-0
trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester

: 1418002-36-4
C₂₂H₂₉N₅O₃

Guidance literature:: (R)-lactamide; With triethyloxonium fluoroborate; In tetrahydrofuran; at 20 ℃; for 2h;

trans-[4-(3-amino-[1,5]naphthyridin-4-ylamino)-cyclohexyl]-carbamic acid tert-butyl ester; In ethanol; for 2h; Reflux;