methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate

Base Information

• Chemical Name: methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate
• CAS No.: 1452855-75-2
• Molecular Formula: C₂₇H₃₁NO₆
• Molecular Weight: 465.546
• Mol file: 1452855-75-2.mol

Synonyms:methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate

Chemical Property of methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate

There total 2 articles about methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

methyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate (79481-83-7) + hydroquinone (123-31-9,8027-02-9) → methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate (1452855-75-2)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 6h; Inert atmosphere;

Reference yield:

chlorambucil (305-03-3) → methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate (1452855-75-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / 18 h / 55 °C

2: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

With potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; potassium iodide; In N,N-dimethyl-formamide;

Reference yield: 85.0%

methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate (1452855-75-2) → 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoic acid (1452855-76-3)

Guidance literature:

methyl 4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoate; With hydrogenchloride; water; Reflux;

With ammonium hydroxide; In water; pH=7;

upstream raw materials:

chlorambucil

methyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

hydroquinone

Downstream raw materials:

4-(4-(bis(2-(4-hydroxyphenoxy)ethyl)amino)phenyl)butanoic acid