Technology Process of N-(3-benzylamino-6-chloro-9H-β-carbolin-8-yl)-2,2,3,3,4,4,4-heptafoluorobutanamide
There total 11 articles about N-(3-benzylamino-6-chloro-9H-β-carbolin-8-yl)-2,2,3,3,4,4,4-heptafoluorobutanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere
2: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere
3: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere
4: dmap / chloroform / 3 h / 20 °C / Inert atmosphere
With
hydrogenchloride; dmap; tin(II) chloride dihdyrate; sodium cyanoborohydride; acetic acid;
In
methanol; chloroform; water;
DOI:10.1016/j.bmcl.2012.03.077
- Guidance literature:
-
Multi-step reaction with 13 steps
1: thionyl chloride / 24 h / 0 °C / Reflux; Inert atmosphere
2: trichloroisocyanuric acid; triethylamine / N,N-dimethyl-formamide / 2 h / -20 - 0 °C / Inert atmosphere
3: N-chloro-succinimide / ethyl acetate / 18 h / Inert atmosphere; Reflux
4: hydrazine hydrate / pentan-1-ol / 7 h / Reflux; Inert atmosphere
5: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere
6: acetic acid / water / 1 h / Reflux; Inert atmosphere
7: chloroform / 0.5 h / 40 °C / Inert atmosphere
8: sodium nitrate; trifluoroacetic acid / 18 h / 0 - 20 °C / Inert atmosphere
9: hydrogenchloride / water / 12 h / Reflux; Inert atmosphere
10: acetic acid / methanol / 4 h / 20 °C / pH 4 / Inert atmosphere
11: sodium cyanoborohydride / methanol / 1 h / 20 °C / Inert atmosphere
12: hydrogenchloride; tin(II) chloride dihdyrate / methanol; water / 48 h / 0 - 20 °C / Inert atmosphere
13: dmap / chloroform / 3 h / 20 °C / Inert atmosphere
With
hydrogenchloride; dmap; sodium nitrate; N-chloro-succinimide; thionyl chloride; tin(II) chloride dihdyrate; trichloroisocyanuric acid; sodium cyanoborohydride; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; sodium nitrite;
In
methanol; pentan-1-ol; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;
6: Curtius rearrangement;
DOI:10.1016/j.bmcl.2012.03.077
