(2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID

Base Information

• Chemical Name: (2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID
• CAS No.: 3585-52-2
• Molecular Formula: C11H14 O2
• Molecular Weight: 178.231
• Mol file: 3585-52-2.mol

Synonyms:Hydratropicacid, p-ethyl- (7CI,8CI); 2-(4-Ethylphenyl)propionic acid;2-(p-Ethylphenyl)propionic acid; p-Ethylhydratropic acid

Chemical Property of (2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID

Chemical Property:

• Melting Point: 35-38℃
• Boiling Point: 135 °C(Press: 3.5 Torr)
• PKA: 4.43±0.10(Predicted)
• PSA: 37.30000
• Density: 1.067
• LogP: 2.43710
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

p-EthylhydratropicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: p-Ethylhydratropic Acid is a phenylacetic acid with potential antiinflammatory activities. p-Ethylhydratropic Acid is an impurity of Ibuprofen (I140000). p-Ethylhydratropic Acid (Ibuprofen EP Impurity N) is a phenylacetic acid with potential antiinflammatory activities. p-Ethylhydratropic Acid is an impurity of Ibuprofen (I140000).

Technology Process of (2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID

There total 9 articles about (2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2-(4-ethylphenyl)propionate (56442-59-2) → α-(4-ethylphenyl)propanoic acid (3585-52-2)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃; for 3h;

Reference yield: 82.0%

α-chloro-4-ethylpropiophenone (132560-66-8) → α-(4-ethylphenyl)propanoic acid (3585-52-2)

Guidance literature:

With water; methyloxirane; In acetone; for 3h; Irradiation;

DOI:10.1016/S0040-4039(00)88526-3

Reference yield: 6.0%

α-chloro-4-ethylpropiophenone (132560-66-8) → α-(4-ethylphenyl)propanoic acid (3585-52-2) + 1-(4-ethylphenyl)-1-propanone (27465-51-6)

Guidance literature:

With methyloxirane; In water; acetone; Irradiation; pH neutral;

DOI:10.1016/S0040-4020(01)80835-8

upstream raw materials:

carbon dioxide

1,4-diethylbenzene

α-chloro-4-ethylpropiophenone

ethyl 2-(4-ethylphenyl)propionate