oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E)

Base Information

Chemical Name:oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E)
CAS No.:102192-11-0
Molecular Formula:C₂₈H₂₁N₃O₇
Molecular Weight:511.491
Hs Code.:

Synonyms:oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E)

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Chemical Property of oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E)

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Technology Process of oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E)

There total 1 articles about oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 6780-38-7
N-phthaloylglycine chloride

: 7352-64-9
glycine 4-nitrobenzyl ester

: 102192-11-0
oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E)

Guidance literature:: With magnesium sulfate; triethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 30 min, room temp. 2.) CH₂Cl₂, 30 min, reflux;

Reference yield: 97.0%

: 102192-11-0
oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E)

: 102192-12-1
[(3S,4R)-3-Amino-2-oxo-4-((E)-styryl)-azetidin-1-yl]-acetic acid 4-nitro-benzyl ester

Guidance literature:: With hydrazine hydrate; In 1,4-dioxane; for 1h; Ambient temperature;

Reference yield:

: 102192-11-0
oxo-2 (phenyl-2 vinyl)-4 phtalimido-3 azetidine-1-acetate de p-nitrobenzyle (3-R,S)(4-S,R)(E)

: 128990-05-6
acide<<(tritylamino-2 thiazolyl-4)(methoxyimino)-acetyl>amino>-7 methoxy-3 oxo-8 thia-4 aza-1 bicyclo<4.2.0> octene-2 carboxylique-2(6-R,S)(7-R,S)(Z)

Guidance literature:: Multi-step reaction with 10 steps

1: 97 percent / hydrazine hydrate / dioxane / 1 h / Ambient temperature

2: 63 percent / tetrahydrofuran / 1 h / Heating

3: 1.) ozone 2.) dimethyl sulfide / 1.) CH₂Cl₂, -70 deg C 2.) CH₂Cl₂, 1 h, room temp.

4: 91 percent / acetic acid, sodium cyanoborohydride / tetrahydrofuran / 1 h / Ambient temperature

5: 72 percent / pyridine / 24 h / Ambient temperature

6: lithium bis(trimethylsilylamide) / tetrahydrofuran; toluene / 1 h / Ambient temperature

7: CH₂Cl₂ / 0.5 h / Ambient temperature

8: 40 percent / hydrogen, / 10percent palladium on charcoal / tetrahydrofuran; methanol / 15 h / 1520 Torr

9: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 0.25 h / 0 °C

10: 1.) tosylchloride 2.) triethylamine, KOH / 1.) acetone, 1 h, room temp. 2.) CH₂Cl₂, 2 h, room temp.

With pyridine; potassium hydroxide; dimethylsulfide; trimethylsilyl trifluoromethanesulfonate; hydrogen; sodium cyanoborohydride; ozone; hydrazine hydrate; acetic acid; triethylamine; p-toluenesulfonyl chloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;