N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide

Base Information

• Chemical Name: N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide
• CAS No.: 1448812-15-4
• Molecular Formula: C₂₂H₂₂ClN₅O₂
• Molecular Weight: 423.902
• Mol file: 1448812-15-4.mol

Synonyms:N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide

Chemical Property of N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide

There total 10 articles about N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-((3-amino-4-methoxy-5-chlorobenzyl)amino)-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile hydrochloride (1448812-27-8) + propionyl chloride (79-03-8) → N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide (1448812-15-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

5-((3-amino-4-methoxy-5-chlorobenzyl)amino)-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile hydrochloride (1448812-27-8) + propionic acid (802294-64-0,79-09-4) → N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide (1448812-15-4)

Guidance literature:

With benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 45 ℃;

DOI:10.1016/j.bmcl.2013.06.026

Reference yield:

C19H14ClN5O3 → N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-methoxy-3-chlorophenyl)propionamide (1448812-15-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 0 - 20 °C

2: pyrographite; iron(III) chloride; hydrazine / isopropyl alcohol / 80 °C

3: 1,2-dichloro-ethane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 45 °C

With iron(III) chloride; pyrographite; benzotriazol-1-ol; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; hydrazine; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2013.06.026

upstream raw materials:

5-(3-chloro-4-methoxy-5-nitrobenzyl)amino-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile

5-((3-amino-4-methoxy-5-chlorobenzyl)amino)-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile hydrochloride

propionic acid

(1-ethoxyethylidene)malononitrile