(1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Base Information

Chemical Name:(1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide
CAS No.:201553-45-9
Molecular Formula:C₂₂H₂₆N₂O₃S
Molecular Weight:398.526
Hs Code.:

Synonyms:(1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Suppliers and Price of (1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

There total 5 articles about (1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 35373-92-3
L-phenylalanine methylamide

: 201553-43-7
(1S,5R,6S)-6-Phenylsulfanylmethyl-3-oxa-bicyclo[3.1.0]hexan-2-one

: 201553-45-9
(1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Guidance literature:: With 2-hydroxypyridin; In toluene; for 48h; Heating;
DOI:10.1016/S0960-894X(97)10171-8

Reference yield:

: 882-33-7
diphenyldisulfane

: 201553-45-9
(1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / tributylphosphine / tetrahydrofuran / 48 h / Ambient temperature

2: 50 percent / 2-hydroxypyridine / toluene / 48 h / Heating

With 2-hydroxypyridin; tributylphosphine; In tetrahydrofuran; toluene;
DOI:10.1016/S0960-894X(97)10171-8

Reference yield:

: 201553-41-5
(1R,5S,6S)-6-Hydroxymethyl-3-oxa-bicyclo[3.1.0]hexan-2-one

: 201553-45-9
(1S,2R,3S)-2-Hydroxymethyl-3-phenylsulfanylmethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / tributylphosphine / tetrahydrofuran / 48 h / Ambient temperature

2: 50 percent / 2-hydroxypyridine / toluene / 48 h / Heating

With 2-hydroxypyridin; tributylphosphine; In tetrahydrofuran; toluene;
DOI:10.1016/S0960-894X(97)10171-8