N-BOC-3-CYCLOHEXYLAMINO-PROPAN-1-OL

Base Information

• Chemical Name: N-BOC-3-CYCLOHEXYLAMINO-PROPAN-1-OL
• CAS No.: 266690-55-5
• Molecular Formula: C14H27 N O3
• Molecular Weight: 257.373
• Hs Code.: 2924299090
• Mol file: 266690-55-5.mol

Synonyms:N-BOC-3-CYCLOHEXYLAMINO-PROPAN-1-OL ;Cyclohexyl-(3-hydroxy-propyl)-carbamic acid tert-butyl ester

Chemical Property of N-BOC-3-CYCLOHEXYLAMINO-PROPAN-1-OL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.49
• Boiling Point: 366.1°Cat760mmHg
• Flash Point: 175.2°C
• PSA: 49.77000
• Density: 1.03g/cm³
• LogP: 2.93860
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

tert-Butylcyclohexyl(3-hydroxypropyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-3-CYCLOHEXYLAMINO-PROPAN-1-OL

There total 2 articles about N-BOC-3-CYCLOHEXYLAMINO-PROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethyl N-tert-butoxycarbonyl-3-cyclohexylamino-propanoate (266690-54-4) → N-tert-butoxycarbonyl-3-cyclohexylamino-propanol (266690-55-5)

Guidance literature:

ethyl N-tert-butoxycarbonyl-3-cyclohexylamino-propanoate; With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h;

With citric acid; In tetrahydrofuran; water; ethyl acetate;

Reference yield: 71.0%

di-tert-butyl dicarbonate (24424-99-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + propan-1-ol-3-amine (156-87-6) → N-tert-butoxycarbonyl-3-cyclohexylamino-propanol (266690-55-5)

Guidance literature:

cyclohexanone; propan-1-ol-3-amine; In methanol; at 70 ℃; for 6h; Inert atmosphere; Molecular sieve;

With sodium tetrahydroborate; at 0 - 20 ℃; for 3h; Inert atmosphere;

di-tert-butyl dicarbonate; With sodium carbonate; In water; tert-butyl alcohol; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112410

Reference yield:

N-tert-butoxycarbonyl-3-cyclohexylamino-propanol (266690-55-5) → C14H26N4O2

Guidance literature:

N-tert-butoxycarbonyl-3-cyclohexylamino-propanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

With sodium azide; In water; ethyl acetate; N,N-dimethyl-formamide; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112410

upstream raw materials:

ethyl N-tert-butoxycarbonyl-3-cyclohexylamino-propanoate

di-tert-butyl dicarbonate

cyclohexanone

propan-1-ol-3-amine

Refernces

• 1、 -. "Serine protease inhibitor". Page/Page column 12-13. . Retrieved 2010/02/11.