5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester
• CAS No.: 72676-89-2
• Molecular Formula: C₁₄H₁₂N₂O₅
• Molecular Weight: 288.26
• Mol file: 72676-89-2.mol

Synonyms:5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Chemical Property of 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

There total 2 articles about 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,3,5-Triazine (290-87-9) + 4-(4-nitro-phenyl)-3-oxo-butyric acid ethyl ester (62088-12-4) → 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester (72676-89-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Heating;

DOI:10.1002/jhet.5570170229

Reference yield:

→ 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester (72676-89-2)

Guidance literature:

4-(4-Nitrophenyl)-acetessigester, 1,3,5-Triazin, NaOEt;

Reference yield:

5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester (72676-89-2) → 1-ethyl-5-<4-(<5-nitrofurfurylidene>amino)phenyl>-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid (74632-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) anhydrous potassium carbonate, 2.) 5percent potassium hydroxide / 1.) 170-180 deg C, 15 min, 2.) 90-100 deg C, 1 h.

2: 28.4 percent / granulated tin / HCl / 1 h / 100 °C

3: 84 percent / ethanol / 1 h

With potassium hydroxide; tin; potassium carbonate; In hydrogenchloride; ethanol;

DOI:10.1002/jhet.5570170229

upstream raw materials:

1,3,5-Triazine

4-(4-nitro-phenyl)-3-oxo-butyric acid ethyl ester

Downstream raw materials:

1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

1-ethyl-5-<4-(<5-nitrofurfurylidene>amino)phenyl>-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

5-(p-aminophenyl)-1-ethyl-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid