1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

Base Information

• Chemical Name: 1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid
• CAS No.: 72676-94-9
• Molecular Formula: C₁₄H₁₂N₂O₅
• Molecular Weight: 288.26
• Mol file: 72676-94-9.mol

Synonyms:1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

Chemical Property of 1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

There total 4 articles about 1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.7%

1-ethyl-5-phenyl-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid (72676-91-6) → 1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid (72676-94-9) + 1-Ethyl-5-(2-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (74632-22-7)

Guidance literature:

With sulfuric acid; nitric acid; 1.) 5-10 deg C, 75 min, 2.) 25-26 deg C, 2.5 h.;

DOI:10.1002/jhet.5570170229

Reference yield:

4-(4-nitro-phenyl)-3-oxo-butyric acid ethyl ester (62088-12-4) → 1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid (72676-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / sodium ethoxide / ethanol / 1 h / Heating

2: 1.) anhydrous potassium carbonate, 2.) 5percent potassium hydroxide / 1.) 170-180 deg C, 15 min, 2.) 90-100 deg C, 1 h.

With potassium hydroxide; sodium ethanolate; potassium carbonate; In ethanol;

DOI:10.1002/jhet.5570170229

Reference yield:

triethyl phosphate (78-40-0) + 5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester (72676-89-2) → 1-ethyl-5-(p-nitrophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid (72676-94-9)

Guidance literature:

With potassium hydroxide; potassium carbonate; Yield given. Multistep reaction; 1.) 170-180 deg C, 15 min, 2.) 90-100 deg C, 1 h.;

DOI:10.1002/jhet.5570170229

upstream raw materials:

1-ethyl-5-phenyl-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

triethyl phosphate

5-(4-nitro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester

4-(4-nitro-phenyl)-3-oxo-butyric acid ethyl ester

Downstream raw materials:

1-ethyl-5-<4-(<5-nitrofurfurylidene>amino)phenyl>-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid

5-(p-aminophenyl)-1-ethyl-4-oxo-1,4-dihydro-3-pyridinecarboxylic acid