N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide

Base Information

Chemical Name:N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide
CAS No.:259227-24-2
Molecular Formula:C₃₀H₂₅ClN₂O₅S
Molecular Weight:561.058
Hs Code.:

Synonyms:N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide

Suppliers and Price of N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide

There total 6 articles about N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 28395-76-8
3-chloro-4-methoxyphenylisocyanate

: 259227-08-2
N,N-dibenzyl-4-(2-hydroxyacetyl)benzenesulfonamide

: 259227-24-2
N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide

Guidance literature:: 3-chloro-4-methoxyphenylisocyanate; N,N-dibenzyl-4-(2-hydroxyacetyl)benzenesulfonamide; In toluene; for 2h; Heating;

With acetic acid; for 8h; Further stages.; Heating;
DOI:10.1021/jm991106b

Reference yield:

: 61827-67-6
sodium 4-acetylbenzenesulfonate

: 259227-24-2
N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: POCl₃ / 3 h / Heating

2.1: Et₃N / tetrahydrofuran / 20 °C

3.1: 71 percent / CHCl₃ / 1 h / 20 °C

4.1: betaine / ethanol / 5 h / 60 °C

4.2: 76 percent / aq. NaHCO₃ / 0.17 h

5.1: toluene / 2 h / Heating

5.2: 21 percent / AcOH / 8 h / Heating

With betaine; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; chloroform; toluene; 1.1: Chlorination / 2.1: sulfonylation / 3.1: Bromination / 4.1: Hydrolysis / 4.2: Hydrolysis / 5.1: Addition / 5.2: Cyclization;
DOI:10.1021/jm991106b

Reference yield:

: 259227-06-0
4-acetyl-N,N-dibenzylbenzenesulfonamide

: 259227-24-2
N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 71 percent / CHCl₃ / 1 h / 20 °C

2.1: betaine / ethanol / 5 h / 60 °C

2.2: 76 percent / aq. NaHCO₃ / 0.17 h

3.1: toluene / 2 h / Heating

3.2: 21 percent / AcOH / 8 h / Heating

With betaine; In ethanol; chloroform; toluene; 1.1: Bromination / 2.1: Hydrolysis / 2.2: Hydrolysis / 3.1: Addition / 3.2: Cyclization;
DOI:10.1021/jm991106b