28395-76-8

Basic information

• Product Name: 3-CHLORO-4-METHOXYPHENYL ISOCYANATE
• Synonyms: 3-CHLORO-4-METHOXYPHENYL ISOCYANATE;2-chloro-4-isocyanatoanisole;2-chloro-4-isocyanato-1-methoxybenzene;2-Chloro-4-isocyanato-1-methoxy-benze
• CAS NO: 28395-76-8
• Molecular Formula: C₈H₆ClNO₂
• Molecular Weight: 183.59
• EINECS: 249-005-1
• Product Categories: Isocyanates;Nitrogen Compounds;Organic Building Blocks;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 28395-76-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 30-33 °C(lit.)
• Boiling Point: 271.7°Cat760mmHg
• Flash Point: 230 °F
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.00633mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 3-CHLORO-4-METHOXYPHENYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-METHOXYPHENYL ISOCYANATE(28395-76-8)
• EPA Substance Registry System: 3-CHLORO-4-METHOXYPHENYL ISOCYANATE(28395-76-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-36
• RIDADR: UN 2206 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 28395-76-8(Hazardous Substances Data)

Usage

General Description

3-Chloro-4-methoxyphenyl isocyanate, also known by the chemical abbreviation CMPI, is a compound with the molecular formula C8H7ClNO2. It is a highly reactive and toxic chemical that is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. CMPI is known for its isocyanate functional group, which is highly reactive and can easily undergo reactions with nucleophiles to form urea derivatives. 3-CHLORO-4-METHOXYPHENYL ISOCYANATE is also known to be a potent respiratory sensitizer and can cause severe irritation to the skin, eyes, and respiratory system upon contact. It is important to handle CMPI with extreme caution and to use appropriate personal protective equipment when working with this chemical.

InChI:InChI=1/C8H6ClNO2/c1-12-8-3-2-6(10-5-11)4-7(8)9/h2-4H,1H3

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 5345-54-0 3-chloro-4-methoxyaniline 
• 75-44-5 phosgene 

Downstream Products

• 819057-72-2 N-[4-(3-amino-1,2-benzisoxazol-4-yl)phenyl]-N'-(3-chloro-4-methoxyphenyl)urea 
• 19937-59-8 metoxuron 
• 1609464-65-4 C₂₃H₂₉ClN₄O₅ 
• 449170-65-4 C₁₄H₁₂Cl₂N₂O₂ 
• 912262-92-1 C₁₇H₁₄ClN₃O₂ 
• 1259307-74-8 N-(3-chloro-4-methoxyphenyl)-9-methyl-3,9-diazaspiro[5.5]undecane-3-carboxamide trifluoroacetic acid salt 
• 1245211-06-6 C₁₈H₁₃ClF₃N₃O₂ 
• 1192309-52-6 1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea 
• 221219-11-0 (3-chloro-4-methoxy-phenyl)-carbamic acid 2-(4-dibenzylsulfamoyl-phenyl)-2-oxo-ethyl ester 
• 259227-24-2 N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide 
• 92846-38-3 <3-Chlor-4-methoxy-phenylcarbamoylmercapto>-essigsaeure-methylamid 
• 43066-18-8 3-(3-chloro-4-methoxy-phenyl)-6-methyl-[1,3]oxazine-2,4-dione 

Relevant articles and documents

Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization

An electrochemical synthesis of oxazol-2-ones and imidazol-2-ones has been developed via 5-exo-dig cyclization of propargylic carbamates- and ureas-derived amidyl radicals. The electrosynthesis relies on the dual function of 2,2,6,6-tetramethylpiperidin- 1-yl)oxyl (TEMPO) as a redox mediator for amidyl radical formation and an oxygen atom donor. The reactions are conducted under mild conditions using a simple setup and provide convenient access to functionalized oxazol-2-ones and imidazol-2-ones from readily available materials.