28395-76-8

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Chloro-4-methoxyphenyl isocyanate is used as a key intermediate in the production of various pharmaceuticals. Its high reactivity enables the formation of urea derivatives, which are essential components in the development of certain drugs.
Used in Agrochemical Production:
In the agrochemical industry, CMPI serves as an intermediate for the synthesis of compounds that are used in the development of pesticides and other agricultural chemicals, contributing to crop protection and enhancement of agricultural yields.
Safety Precautions:
Given its potent respiratory sensitizing properties and potential for severe skin and eye irritation, 3-CHLORO-4-METHOXYPHENYL ISOCYANATE requires careful handling. It is imperative to utilize personal protective equipment, such as gloves, goggles, and respirators, to minimize exposure risks during its use in chemical synthesis processes.

InChI:InChI=1/C8H6ClNO2/c1-12-8-3-2-6(10-5-11)4-7(8)9/h2-4H,1H3

Upstream product

• 75-44-5 phosgene 
• 5345-54-0 3-chloro-4-methoxyaniline 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 43066-18-8 3-(3-chloro-4-methoxy-phenyl)-6-methyl-[1,3]oxazine-2,4-dione 
• 92846-38-3 <3-Chlor-4-methoxy-phenylcarbamoylmercapto>-essigsaeure-methylamid 
• 19937-59-8 metoxuron 
• 819057-72-2 N-[4-(3-amino-1,2-benzisoxazol-4-yl)phenyl]-N'-(3-chloro-4-methoxyphenyl)urea 
• 1245211-06-6 C₁₈H₁₃ClF₃N₃O₂ 
• 1259307-74-8 N-(3-chloro-4-methoxyphenyl)-9-methyl-3,9-diazaspiro[5.5]undecane-3-carboxamide trifluoroacetic acid salt 
• 912262-92-1 C₁₇H₁₄ClN₃O₂ 
• 449170-65-4 C₁₄H₁₂Cl₂N₂O₂ 
• 221219-11-0 (3-chloro-4-methoxy-phenyl)-carbamic acid 2-(4-dibenzylsulfamoyl-phenyl)-2-oxo-ethyl ester 
• 259227-24-2 N,N-dibenzyl-4-[3-(3-chloro-4-methoxyphenyl)-2-oxo-2,3-dihydrooxazol-4-yl]benzenesulfonamide 
• 1609464-65-4 C₂₃H₂₉ClN₄O₅ 
• 1192309-52-6 1-{4-Chloro-3-[2-(2-dimethylamino-ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]-phenyl}-3-(3-chloro-4-methoxy-phenyl)-urea 

Relevant academic research and scientific papers

Electrochemically Enabled Intramolecular Aminooxygenation of Alkynes via Amidyl Radical Cyclization

An electrochemical synthesis of oxazol-2-ones and imidazol-2-ones has been developed via 5-exo-dig cyclization of propargylic carbamates- and ureas-derived amidyl radicals. The electrosynthesis relies on the dual function of 2,2,6,6-tetramethylpiperidin- 1-yl)oxyl (TEMPO) as a redox mediator for amidyl radical formation and an oxygen atom donor. The reactions are conducted under mild conditions using a simple setup and provide convenient access to functionalized oxazol-2-ones and imidazol-2-ones from readily available materials.

Mesolimbic selective antipsychotic arylcarbamates

4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidine has been linked to various arylcarbamates to obtain compounds having affinity for dopamine-D1 and -D2, serotonin 5HT(2A) and α1-adrenoceptors. When linkers with restricted flexibility are used, the biological activity is reduced indicating that a bended conformation is needed in this series of bioactive molecules. Compounds with a relatively low D2/5HT(2A) affinity ratio in receptor binding experiments and high affinity for the α1-adrenoceptors exhibit a pharmacological profile which suggests a preferential effect on the mesocorticolimbic dopaminergic system and an 'atypical' antipsychotic activity.