methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate

Base Information

Chemical Name:methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate
CAS No.:1352083-17-0
Molecular Formula:C₁₈H₂₄N₂O₅
Molecular Weight:348.399
Hs Code.:

Synonyms:methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate

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Chemical Property of methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate

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Technology Process of methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate

There total 1 articles about methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 619-45-4
4-methoxycarbonyl aniline

: 120728-10-1
1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid

: 1352083-17-0
methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield: 68.0%

: 1352083-17-0
methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate

: 1352083-18-1
4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoic acid

Guidance literature:: methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate; With lithium hydroxide monohydrate; water; In 1,4-dioxane; isopropyl alcohol; at 60 ℃; for 0.75h;

With hydrogenchloride; In 1,4-dioxane; water; isopropyl alcohol; at 20 ℃;

Reference yield:

: 1352083-17-0
methyl 4-[({1-[(tert-butoxycarbonyl)amino]cyclobutyl}carbonyl)amino]benzoate

: 1352082-81-5
3-cyclohexyl-N-[1-({4-[(methylsulfonyl)carbamoyl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide monohydrate / isopropyl alcohol; 1,4-dioxane / 0.75 h / 60 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide; isopropyl alcohol;