3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

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Chemical Name:3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide
CAS No.:1312593-06-8
Molecular Formula:C₂₅H₂₄ClN₃O₃S₂
Molecular Weight:514.069
Hs Code.:

Synonyms:3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

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Chemical Property of 3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

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Technology Process of 3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

There total 8 articles about 3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 1312593-02-4
N-{2-bromo-6-methyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-chlorobenzenesulfonamide

: 1312593-06-8
3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; at 70 ℃; for 19h;

Reference yield:

: 586-37-8
1-(3-Methoxyphenyl)ethanone

: 1312593-06-8
3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 16 h / 70 °C / Inert atmosphere

2.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 0.75 h / 35 °C / Inert atmosphere

3.1: tin(IV) chloride / toluene / 3.5 h / 20 °C / Reflux

3.2: 20 °C

4.1: N-Bromosuccinimide / dichloromethane / 0.75 h / 20 °C

5.1: sodium hydroxide; water / dimethyl sulfoxide / 1 h / 150 °C

5.2: 20 °C / pH 6

6.1: copper; quinoline / 1 h / 180 - 190 °C / microwave irradiation

7.1: sodium t-butanolate / tetrahydrofuran / 0.25 h / 20 °C

7.2: 3.5 h

8.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / tetrahydrofuran / 19 h / 70 °C

With quinoline; N-Bromosuccinimide; water; tin(IV) chloride; copper; sodium hydrogencarbonate; caesium carbonate; sulfur; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 86604-43-5
2-(1-(3-methoxyphenyl)ethylidene)malononitrile

: 1312593-06-8
3-chloro-N-[6-methyl-3-[3-(methyloxy)phenyl]-2-(1-pyrrolidinyl)thieno[2,3-b]pyridin-4-yl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 0.75 h / 35 °C / Inert atmosphere

2.1: tin(IV) chloride / toluene / 3.5 h / 20 °C / Reflux

2.2: 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 0.75 h / 20 °C

4.1: sodium hydroxide; water / dimethyl sulfoxide / 1 h / 150 °C

4.2: 20 °C / pH 6

5.1: copper; quinoline / 1 h / 180 - 190 °C / microwave irradiation

6.1: sodium t-butanolate / tetrahydrofuran / 0.25 h / 20 °C

6.2: 3.5 h

7.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / tetrahydrofuran / 19 h / 70 °C

With quinoline; N-Bromosuccinimide; water; tin(IV) chloride; copper; sodium hydrogencarbonate; caesium carbonate; sulfur; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;