5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

Base Information

Chemical Name:5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide
CAS No.:311334-85-7
Molecular Formula:C₂₅H₂₃ClF₆N₄O₂
Molecular Weight:560.927
Hs Code.:

Synonyms:5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

Suppliers and Price of 5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

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Chemical Property of 5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

There total 6 articles about 5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 311334-77-7
5-(2-Chloro-phenyl)-2-methylsulfonyl-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 311334-85-7
5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

Guidance literature:: With caesium carbonate; In acetonitrile; for 16h;

Reference yield:

: 74840-38-3
ethyl 5-bromo-2-methylthio-4-pyrimidinecarboxylate

: 311334-85-7
5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 105 °C

2.1: sodium hydroxide / ethanol / 1 h / 20 °C

2.2: pH 1

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 5 - 20 °C

5.1: caesium carbonate / acetonitrile / 16 h

With sodium hydroxide; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 311334-85-7
5-(2-chloro-phenyl)-2-(2-dimethylamino-ethoxy)-pyrimidine-4-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 105 °C

2.1: sodium hydroxide / ethanol / 1 h / 20 °C

2.2: pH 1

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 16 h

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 5 - 20 °C

5.1: caesium carbonate / acetonitrile / 16 h

With sodium hydroxide; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;