3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Base Information

• Chemical Name: 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester
• CAS No.: 439292-92-9
• Molecular Formula: C₃₃H₃₆N₄O₇
• Molecular Weight: 600.671
• Mol file: 439292-92-9.mol

Synonyms:3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Chemical Property of 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester

There total 1 articles about 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

t-butoxycarbonylhydrazine (870-46-2) + tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester → 3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester (439292-92-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 21h;

DOI:10.1021/ol025895u

Reference yield: 99.0%

3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester (439292-92-9) → (3S)-N(1)-Z-piperazic acid t-butylhydrazide (439292-93-0)

Guidance literature:

With diethylamine; In acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1021/ol025895u

Reference yield:

3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1,2-dicarboxylic acid 1-benzyl ester 2-(9H-fluoren-9-ylmethyl) ester (439292-92-9) → (S)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-4-methyl-pentanoyl]-3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester (439292-97-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 99 percent / diethylamine / acetonitrile / 0.25 h / 20 °C

2.1: 90 percent / AgCN / benzene / 0.83 h / 80 °C

3.1: 84 percent / diethylamine / acetonitrile / 0.25 h / 20 °C

4.1: BOP-Cl; collidine / CH₂Cl₂ / 0.33 h / -20 °C

4.2: 66 percent / collidine / CH₂Cl₂ / 16 h / 20 °C

5.1: 83 percent / diethylamine / acetonitrile / 0.25 h / 20 °C

With 2,3,5-trimethyl-pyridine; silver cyanide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylamine; In dichloromethane; acetonitrile; benzene;

DOI:10.1021/ol025895u

upstream raw materials:

t-butoxycarbonylhydrazine

Downstream raw materials:

(3S)-N⁽¹⁾-Z-piperazic acid t-butylhydrazide

3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-2-(4-methyl-2-methylamino-pentanoyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-2-{2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-4-methyl-pentanoyl}-tetrahydro-pyridazine-1-carboxylic acid benzyl ester

(S)-2-[(R)-2-({(S)-2-[Benzyloxy-((R)-1-benzyloxycarbonyl-hexahydro-pyridazine-3-carbonyl)-amino]-propionyl}-methyl-amino)-4-methyl-pentanoyl]-3-(N'-tert-butoxycarbonyl-hydrazinocarbonyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester