UPR 1157

Base Information

Chemical Name:UPR 1157
CAS No.:1233953-79-1
Molecular Formula:C₁₉H₂₀BrN₅O
Molecular Weight:414.305
Hs Code.:

Synonyms:UPR 1157

Suppliers and Price of UPR 1157

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of UPR 1157

Chemical Property:

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Technology Process of UPR 1157

There total 5 articles about UPR 1157 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1233953-80-4
N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-3-chloropropanamide

: 124-40-3
dimethyl amine

: 1233953-79-1
UPR 1157

Guidance literature:: N-(4-((3-bromophenyl)amino)quinazolin-6-yl)-3-chloropropanamide; dimethyl amine; With sodium iodide; In ethanol; for 8.25h; Reflux;

With potassium hydroxide; In ethanol; at 0 ℃; for 1h;

Reference yield:

: 169205-78-1
6-amino-4-[(3-bromophenyl)amino]quinazoline

: 1233953-79-1
UPR 1157

Guidance literature:: Multi-step reaction with 2 steps

1.1: 5 h / 50 °C

2.1: potassium iodide / ethanol / 8.25 h / Reflux

2.2: 1 h / 0 °C

With potassium iodide; In ethanol;
DOI:10.1021/jm201507x

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 1233953-79-1
UPR 1157

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / Reflux

2.1: thionyl chloride / 1,4-dioxane / Reflux

2.2: 60 °C

3.1: iron; acetic acid / ethanol; water / Reflux

4.1: 5 h / 50 °C

5.1: potassium iodide / ethanol / 8.25 h / Reflux

5.2: 1 h / 0 °C

With thionyl chloride; sulfuric acid; iron; acetic acid; potassium iodide; In 1,4-dioxane; ethanol; water;
DOI:10.1021/jm201507x