(2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol

Base Information

Chemical Name:(2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol
CAS No.:172147-87-4
Molecular Formula:C₃₂H₅₄O₆Si₂
Molecular Weight:590.948
Hs Code.:

Synonyms:(2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol

Suppliers and Price of (2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol

Chemical Property:

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Technology Process of (2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol

There total 4 articles about (2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 36199-02-7
3,4-di-O-benzyl-D-mannitol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 172147-87-4
(2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.3390/ph12030108

Reference yield:

: 69-65-8
mannitol

: 172147-87-4
(2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / p-TsOH / dimethylsulfoxide / 16 h / Ambient temperature

2: 61 percent / NaOH, TBAHSO₄ / 22 h / 40 °C

3: 75 percent / AcOH 80percent / H₂O

4: 65 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; toluene-4-sulfonic acid; acetic acid; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01361-6

Reference yield:

: 111476-62-1
3,4-di-O-benzyl-1,2:5,6-di-O-isopropylidene-D-mannitol

: 172147-87-4
(2R,3R,4R,5R)-3,4-Bis-benzyloxy-1,6-bis-(tert-butyl-dimethyl-silanyloxy)-hexane-2,5-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / AcOH 80percent / H₂O

2: 65 percent / imidazole / dimethylformamide

With 1H-imidazole; acetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01361-6