4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

Base Information

• Chemical Name: 4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester
• CAS No.: 221690-25-1
• Molecular Formula: C₃₃H₃₉NO₄
• Molecular Weight: 513.677

Synonyms:4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

Chemical Property of 4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

There total 2 articles about 4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3,3-dimethyl-butan-2-one (75-97-8) + tert-butyl (2S)-2-[(9-phenyl-9-fluorenyl)amino]-4-oxobutanoate (215182-76-6) → 4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester (221690-25-1)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1021/jo982181h

Reference yield:

N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester (120230-41-3) → 4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester (221690-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / DIBAL-H / toluene / 0.42 h / -78 °C

2: 84 percent / n-BuLi, diisopropylamine / tetrahydrofuran; hexane / -78 °C

With n-butyllithium; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; hexane; toluene;

DOI:10.1021/jo982181h

Reference yield: 87.0%

4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester (221690-25-1) → 7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester (221690-40-0)

Guidance literature:

With copper(l) chloride; diisopropyl-carbodiimide; In tetrahydrofuran; for 14h; Heating;

DOI:10.1021/jo982181h

upstream raw materials:

3,3-dimethyl-butan-2-one

tert-butyl (2S)-2-[(9-phenyl-9-fluorenyl)amino]-4-oxobutanoate

N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester

Downstream raw materials:

7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-oct-4-enoic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 221690-25-1 4-hydroxy-7,7-dimethyl-6-oxo-2-(9-phenyl-9H-fluoren-9-ylamino)-octanoic acid tert-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send