3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione
• CAS No.: 1178564-34-5
• Molecular Formula: C₁₉H₁₃ClN₂O₂
• Molecular Weight: 336.777
• Mol file: 1178564-34-5.mol

Synonyms:3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

Chemical Property of 3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

There total 2 articles about 3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.7%

4-chloro-3-(1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione (959418-00-9) + methyl iodide (74-88-4) → 3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione (1178564-34-5)

Guidance literature:

With potassium carbonate; copper(II) oxide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.2174/1570180811310050003

Reference yield:

3,4-dichloro-1-phenyl-1H-pyrrole-2,5-dione (3876-05-9) → 3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione (1178564-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / diethyl ether; benzene / 0.5 h / 20 °C

1.2: 20 °C

2.1: potassium carbonate; copper(II) oxide / N,N-dimethyl-formamide / 4 h / 20 °C

With ethylmagnesium bromide; potassium carbonate; copper(II) oxide; In diethyl ether; N,N-dimethyl-formamide; benzene;

DOI:10.2174/1570180811310050003

Reference yield: 95.0%

4-Octyne (1942-45-6) + 3-chloro-4-(1-methyl-1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione (1178564-34-5) → 6-methyl-2-phenyl-4,5-dipropylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

Guidance literature:

With palladium diacetate; diisopropylamine; tricyclohexylphosphine tetrafluoroborate; In dimethyl sulfoxide; at 135 ℃; for 52h; Inert atmosphere;

upstream raw materials:

4-chloro-3-(1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

methyl iodide

3,4-dichloro-1-phenyl-1H-pyrrole-2,5-dione

Downstream raw materials:

3-(1-methyl-1H-indol-3-yl)-4-(1H-pyrazolo[3,4-b]pyridin-3-yl)-1-phenyl-1H-pyrrole-2,5-dione

3-(1-methyl-1H-indol-3-yl)-1-phenyl-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-1H-pyrrole-2,5-dione