(3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole

Base Information

Chemical Name:(3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole
CAS No.:869991-61-7
Molecular Formula:C₂₅H₃₁Br₂ClN₂Si
Molecular Weight:582.881
Hs Code.:

Synonyms:(3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole

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Chemical Property of (3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole

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Technology Process of (3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole

There total 6 articles about (3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67754-00-1
(E)-trichloro-(β-methylcrotyl)silane

: 546084-44-0
(1R,2R)-N,N'-di(4'-bromobenzyl)-1,2-diaminocyclohexane

: 869991-61-7
(3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole

Guidance literature:: (E)-trichloro-(β-methylcrotyl)silane; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

(1R,2R)-N,N'-di(4'-bromobenzyl)-1,2-diaminocyclohexane; In dichloromethane; at 0 - 20 ℃; for 19.5h; Inert atmosphere;
DOI:10.1021/acs.orglett.5b01601

Reference yield:

: 78-79-5,9003-31-0
isoprene

: 869991-61-7
(3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Cl₃SiH / Pd(PPh₃)4 / 15 h / 25 °C

2: 69 percent / diazabicycloundecane / CH₂Cl₂ / 0 - 20 °C

With diazabicycloundecane; trichlorosilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane;
DOI:10.1021/jo051525i

Reference yield:

: 80-59-1
Tiglic acid

: 869991-61-7
(3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

2.1: 1,1,1,3,3,3-hexachloro-propan-2-one; triphenylphosphine / 5 - 20 °C / Inert atmosphere

3.1: copper(l) chloride; tributyl-amine; trichlorosilane / diethyl ether / 25 h / 0 - 20 °C / Inert atmosphere

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

4.2: 19.5 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tributyl-amine; 1,1,1,3,3,3-hexachloro-propan-2-one; trichlorosilane; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; copper(l) chloride; In diethyl ether; dichloromethane;
DOI:10.1021/acs.orglett.5b01601