(+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Base Information

Chemical Name:(+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide
CAS No.:1058073-37-2
Molecular Formula:C₂₉H₃₄ClN₃O₄S
Molecular Weight:556.126
Hs Code.:

(+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Synonyms:(+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Property of (+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Technology Process of (+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

There total 13 articles about (+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1058073-32-7
(+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(hydroxymethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

: 1058073-37-2
(+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: With thionyl chloride; In chloroform; at 20 ℃; for 2 - 3h;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 1058073-37-2
(+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

1.2: 1 h / 2 - 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2 h / 22 - 50 °C

2.2: 21 - 24 h / 20 - 30 °C

3.1: lithium chloride / ethanol; water; toluene / 0.25 h

3.2: 0.17 h

3.3: 20 h / 70 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

5.2: 0.5 h / 30 °C

6.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 - 23 °C

7.1: thionyl chloride / chloroform / 2 - 3 h / 20 °C

With lithium hydroxide; thionyl chloride; water; sodium hydride; diisobutylaluminium hydride; caesium carbonate; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 494799-76-7
2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1058073-37-2
(+/-)-8-cyclohexyl-N-(dimethylaminosulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-(chloromethyl)-cycloprop[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 - 2 h / 22 - 50 °C

1.2: 21 - 24 h / 20 - 30 °C

2.1: lithium chloride / ethanol; water; toluene / 0.25 h

2.2: 0.17 h

2.3: 20 h / 70 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 55 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 30 °C

4.2: 0.5 h / 30 °C

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 3 h / -78 - 23 °C

6.1: thionyl chloride / chloroform / 2 - 3 h / 20 °C

With thionyl chloride; sodium hydride; diisobutylaluminium hydride; caesium carbonate; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;