(R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol

Base Information

Chemical Name:(R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol
CAS No.:831235-42-8
Molecular Formula:C₄₃H₆₀O₄Si
Molecular Weight:669.033
Hs Code.:

(R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol

Synonyms:(R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol

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Chemical Property of (R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol

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Technology Process of (R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol

There total 1 articles about (R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (1R,3S,4aR,5R,8aS)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-methyl-propyl]-3-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalene

: 831235-42-8
(R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1021/jo048456c

Reference yield: 98.0%

: 124-63-0
methanesulfonyl chloride

: 831235-42-8
(R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol

: 831235-43-9
Methanesulfonic acid (R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jo048456c

Reference yield:

: 831235-42-8
(R)-2-{(1R,4aS,5R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl}-3-methyl-butan-1-ol

: 831235-52-0
(S)-2-[(1R,3S,4aR,5R,8aS)-5-[(R)-1-(2-Amino-phenylsulfanylmethyl)-2-methyl-propyl]-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 3 h / 0 °C

2: 95 percent / DDQ; H₂O / CH₂Cl₂ / 0.5 h / 20 °C

3: 91 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 3 h / -78 °C

4: 97 percent / 2-methyl-2-butene; aq. NaClO₂; NaH₂PO₄*H₂O / 2-methyl-propan-2-ol; acetonitrile / 2 h / 20 °C

5: 97 percent / NaH / tetrahydrofuran; dimethylformamide / 8 h / 55 °C

6: 91 percent / Zn; NH₄Cl / methanol / 3 h / Heating

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; water; sodium hydride; ammonium chloride; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 3: Swern oxidation;
DOI:10.1021/jo048456c