1-(6-Morpholino-3-pyridinyl)-1-ethanone

Base Information

• Chemical Name: 1-(6-Morpholino-3-pyridinyl)-1-ethanone
• CAS No.: 265107-43-5
• Molecular Formula: C11H14 N2 O2
• Molecular Weight: 206.24
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID80443057
• Wikidata: Q82260749
• Mol file: 265107-43-5.mol

Synonyms:265107-43-5;1-(6-morpholinopyridin-3-yl)ethanone;1-(6-morpholino-3-pyridinyl)-1-ethanone;1-(6-morpholin-4-ylpyridin-3-yl)ethanone;1-[6-(Morpholin-4-yl)pyridin-3-yl]ethan-1-one;1-[6-(Morpholin-4-yl)pyridin-3-yl]ethanone;SCHEMBL209882;DTXSID80443057;OFDRYHNFFIICNW-UHFFFAOYSA-N;MFCD09910348;AKOS005073677;NB-0600;FT-0681231;1-(6-Morpholin-4-yl-pyridin-3-yl)-ethanone;A818480;J-503474

Chemical Property of 1-(6-Morpholino-3-pyridinyl)-1-ethanone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 78-80°
• Refractive Index: 1.546
• Boiling Point: 408.302°C at 760 mmHg
• PKA: 3.40±0.10(Predicted)
• Flash Point: 200.734°C
• PSA: 42.43000
• Density: 1.162g/cm³
• LogP: 1.18580
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 206.105527694
• Heavy Atom Count: 15
• Complexity: 227

Purity/Quality:

97% ^*data from raw suppliers

1-(6-Morpholino-3-pyridinyl)-1-ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CN=C(C=C1)N2CCOCC2

Technology Process of 1-(6-Morpholino-3-pyridinyl)-1-ethanone

There total 6 articles about 1-(6-Morpholino-3-pyridinyl)-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 3-acetyl-6-chloropyridine (55676-22-7) → 1-(6-morpholin-4-yl-pyridin-3-yl)-ethanone (265107-43-5)

Guidance literature:

In ethanol; for 12h; Heating / reflux;

Reference yield: 59.1%

tributyl(1-ethoxyvinyl)stannane (97674-02-7) + 5-bromo-2-(4-morpholinyl)pyridine (200064-11-5) → 1-(6-morpholin-4-yl-pyridin-3-yl)-ethanone (265107-43-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 100 ℃; for 12h;

Reference yield:

6-Chloronicotinoyl chloride (58757-38-3) → 1-(6-morpholin-4-yl-pyridin-3-yl)-ethanone (265107-43-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: MgCl₂; Et₃N / toluene / 1 h / 20 °C

1.2: toluene / 0.33 h

2.1: 40.2 g / dimethylsulfoxide; H₂O / 2 h / 150 °C

3.1: 68 percent / ethanol

With triethylamine; magnesium chloride; In ethanol; water; dimethyl sulfoxide; toluene;

DOI:10.1016/j.bmc.2005.03.023

upstream raw materials:

morpholine

3-acetyl-6-chloropyridine

6-Chloronicotinoyl chloride

dimethyl 2-(6-chloronicotinoyl)malonate

Downstream raw materials:

6-amino-4-cyclohexyl-6'-morpholin-4-yl-[2,3']bipyridinyl-5-carbonitrile

2-amino-4-(3-bromophenyl)-6-[2-(4-morpholinyl)-5-pyridyl]nicotinonitrile

6-amino-4-(cyclohexyl-methyl-amino)-6'-morpholin-4-yl-[2,3']bipyridinyl-5-carbonitrile

4-(6-(morpholin-4-yl)pyridin-3-yl)-N-(3-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)pyrimidin-2-amine