trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt

Base Information

Chemical Name:trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt
CAS No.:126111-10-2
Molecular Formula:C₇H₈O₃S*C₁₁H₁₉NO₄
Molecular Weight:401.481
Hs Code.:

Synonyms:trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt

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Chemical Property of trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt

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Technology Process of trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt

There total 5 articles about trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 126111-26-0
trans-4-(2,2-dimethyl-1-oxopropoxy)-1-<(phenylmethoxy)carbonyl>-L-proline methyl ester

: 104-15-4
toluene-4-sulfonic acid

: 126111-10-2
trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2.5h; under 2068.6 Torr;
DOI:10.1021/jm00167a028

Reference yield:

: 3282-30-2
pivaloyl chloride

: 126111-10-2
trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 3 h / Ambient temperature

2: 76 percent / H₂ / 10percent Pd/C / ethyl acetate / 2.5 h / 2068.6 Torr

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm00167a028

Reference yield:

: 64187-48-0
methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate

: 126111-10-2
trans-4-(2,2-dimethyl-1-oxopropoxy)-L-proline methyl ester 4-methylbenzenesulfonate salt

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 3 h / Ambient temperature

2: 76 percent / H₂ / 10percent Pd/C / ethyl acetate / 2.5 h / 2068.6 Torr

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm00167a028