Technology Process of Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, ethyl ester
There total 2 articles about Acetic acid, 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-, ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: nitric acid / water; dichloromethane
2.1: palladium on activated charcoal; hydrogen; oxalic acid / ethanol
3.1: ethyl acetate
4.1: ethanol
5.1: triethylamine / ethanol
6.1: potassium carbonate / N,N-dimethyl-formamide
7.1: N-Bromosuccinimide / tetrahydrofuran
8.1: sodium hydroxide; water / toluene
9.1: oxalyl dichloride / dichloromethane / 0.42 h / 5 - 10 °C
9.2: 0.33 h / 0 - 20 °C
With
N-Bromosuccinimide; oxalyl dichloride; palladium on activated charcoal; water; hydrogen; nitric acid; oxalic acid; potassium carbonate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / tetrahydrofuran
2.1: sodium hydroxide; water / toluene
3.1: oxalyl dichloride / dichloromethane / 0.42 h / 5 - 10 °C
3.2: 0.33 h / 0 - 20 °C
With
N-Bromosuccinimide; oxalyl dichloride; water; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; toluene;
- Guidance literature:
-
With
sodium hydroxide;
In
tetrahydrofuran;
at 10 - 15 ℃;
Reagent/catalyst;