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878672-00-5

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Product FOB Price Min.Order Supply Ability Supplier
Lesinurad
Cas No: 878672-00-5
No Data 1 Gram 10 Kilogram/Day Hangzhou Hysen Pharma co.,Ltd. Contact Supplier
Lessinurad
Cas No: 878672-00-5
USD $ 999.0-999.0 / Gram 1 Gram 1 Metric Ton/Month Shanghai Run-Biotech Co., Ltd. Contact Supplier
RDAE 594,878672-00-5
Cas No: 878672-00-5
No Data No Data 1 Metric Ton/Day Wuhan MoonZY Biological Technology Co.,Ltd Contact Supplier
Lesinurad
Cas No: 878672-00-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Lesinurad
Cas No: 878672-00-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Lesinurad
Cas No: 878672-00-5
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
High purity Lesinurad Cas 878672-00-5 with high quality and best price
Cas No: 878672-00-5
USD $ 7.0-10.0 / Gram 10 Gram 36 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Lesinurad
Cas No: 878672-00-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Kilogram/Month Enke Pharma-tech Co.,Ltd. (Cangzhou, China ) Contact Supplier
Lesinurad
Cas No: 878672-00-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 2000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
RDEA 594 MANUFACTURER
Cas No: 878672-00-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Kilogram/Month LIDE PHARMACEUTICALS LIMITED Contact Supplier

878672-00-5 Usage

Chemical Synthesis

The synthesis of lesinurad began with commercial 1- bromonaphthalene (138). A Kumada coupling between this bromide and cyclopropyl Grignard delivered 139, which after selective nitration to give 140, delivered the oxylate salt 141 (which now is commercially available). Treatment of 141 with KOH followed by thiophosgene at 5 °C delivered isothiocyanate 142 in 63% yield. Reaction of 142 with formyl hydrazine followed by addition of potassium bicarbonate and mild heating resulted in thio-1,2,4-triazole 144 by the intermediacy of 143. Quantitative alkylation of triazolothiol 144 resulted in α-mercaptan 145, and this was followed by NBS bromination to afford bromotriazole 146. Ester saponification followed by acidification secured lesinurad (XVII) in a good yield over the final three steps.

Definition

ChEBI: A member of the class of triazoles that is [(3-bromo-1,2,4-triazol-5-yl)sulfanyl]acetic acid substituted at position 1 of the triazole ring by a 4-cyclopropylnaphthalen-1-yl group. Used for treatment of gout.

Description

Approved by the FDA late in 2015, lesinurad is an urate anion exchange transporter 1 (URAT1) inhibitor for use in the treatment of gout. Ardea Biosciences, which is a subsidiary of AstraZeneca, developed lesinurad to be used in a combination therapy with xanthine oxidase inhibitors for the treatment of hyperuricaemia associated with gout. The approval process is ongoing in several other countries across the globe, with the EMA Committee for Medicinal Products for Human Use giving lesinurad a positive opinion for use as an adjunctive therapy in combination with xanthine oxidase inhibitors to treat hyperuricaemia.

878672-00-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Lesinurad

1.2 Other means of identification

Product number -
Other names RDEA594

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:878672-00-5 SDS

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